Regulation of hepatic ABCC transporters by xenobiotics and in disease states.

摘要: The subfamily of ABCC transporters consists 13 members in mammals, including the multidrug resistance-associated proteins (MRPs), sulfonylurea receptors (SURs), and cystic fibrosis transmembrane conductance regulator (CFTR). These play roles chemical detoxification, disposition, normal cell physiology. are expressed differentially liver regulated at transcription translation level. Their expression function also controlled by post-translational modification membrane-trafficking events. processes tightly regulated. Information about alterations hepatobiliary could provide important insights into pathogenesis diseases disposition xenobiotics. In this review, we describe regulation hepatic humans rodents a variety xenobiotics, under disease states genetically modified animal models deficient factors, transporters, cell-signaling molecules.