In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians.
作者： G. Pepe , V. Di Perna , F. Resta , M. Lovecchio , G. Chimienti
DOI: 10.1016/S0021-9150(97)00290-6
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摘要: Abstract We studied centenarians to investigate the biological basis of human longevity focusing on apolipoprotein A-IV and lipoprotein(a), potentially involved in susceptibility atherogenic mechanisms. analyzed two restriction polymorphisms, HinfI 347 (alleles +, −) Fnu4HI 360 1, 2), a VNTR 3, 4) at 3′ region apo gene. The allele frequencies, lipoprotein concentrations their association adults have been compared. In centenarians, genotype distribution is different ( P 20 mg/dl, value considered as threshold for risk, surprisingly compatible with healthy longevity.
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sci-hub.se 参考文章(42)
D Mari, PM Mannucci, R Coppola, B Bottasso, KA Bauer, RD Rosenberg, Hypercoagulability in centenarians : the paradox of successful aging Blood. ,vol. 85, pp. 3144- 3149 ,(1995) , 10.1182/BLOOD.V85.11.3144.BLOODJOURNAL85113144
Masatoshi Nei, Molecular Evolutionary Genetics ,(1987)
A von Eckardstein, H Funke, G Assmann, M Schulte, H Schulte, M Erren, Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population. American Journal of Human Genetics. ,vol. 50, pp. 1115- 1128 ,(1992)
P. Lohse, M.R. Kindt, D.J. Rader, H.B. Brewer, Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys). Journal of Biological Chemistry. ,vol. 266, pp. 13513- 13518 ,(1991) , 10.1016/S0021-9258(18)92728-6
N A Elshourbagy, D W Walker, Y K Paik, M S Boguski, M Freeman, J I Gordon, J M Taylor, Structure and expression of the human apolipoprotein A-IV gene. Journal of Biological Chemistry. ,vol. 262, pp. 7973- 7981 ,(1987) , 10.1016/S0021-9258(18)47513-8
M Sandkamp, H Funke, H Schulte, E Köhler, G Assmann, Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age. Clinical Chemistry. ,vol. 36, pp. 20- 23 ,(1990) , 10.1093/CLINCHEM/36.1.20
G Utermann, The mysteries of lipoprotein(a) Science. ,vol. 246, pp. 904- 910 ,(1989) , 10.1126/SCIENCE.2530631
Peter Lohse, H Bryan Brewer, Genetic polymorphism of apolipoprotein A-IV Current Opinion in Lipidology. ,vol. 2, pp. 90- 95 ,(1991) , 10.1097/00041433-199104000-00006
G Utermann, H J Menzel, H G Kraft, H C Duba, H G Kemmler, C Seitz, Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. Journal of Clinical Investigation. ,vol. 80, pp. 458- 465 ,(1987) , 10.1172/JCI113093
S. K. Karathanasis, P. Oettgen, I. A. Haddad, S. E. Antonarakis, Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 8457- 8461 ,(1986) , 10.1073/PNAS.83.22.8457