Genomic and non-genomic effects of progesterone on prostaglandin (PG) F2α and PGE2 production in the bovine endometrium
作者： Mariko Kuse , Ryosuke Sakumoto , Kiyoshi Okuda
DOI: 10.1071/RD14490
关键词:
摘要: Progesterone (P4) acts through different actuating pathways called genomic and non-genomic pathways. Here we investigated whether P4 regulates prostaglandin (PG) F2? (PGF) PGE2 production in bovine endometrium Cultured endometrial cells were exposed to for a short time (5-20min) or serum albumin (BSA)-conjugated (P4-BSA) 24h. treatment 24h stimulated epithelial cells, but suppressed both PGF the expression of PG-metabolising enzymes including phospholipase A2 (PLA2) cyclooxygenase-2 (COX2) stromal cells. Short-term did not affect PLA2 COX2 transcript levels either cell type. P4-BSA increased only Nuclear receptor mRNA was higher at follicular phase than early- mid-luteal stages, whereas membrane change throughout oestrous cycle. The overall results suggest that controls PG by inhibiting via pathway stimulating signal transduction pathway. Consequently, may protect corpus luteum attenuating increasing secretion from
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A P F Flint, W M F Leat, E L Sheldrick, H J Stewart, Stimulation of phosphoinositide hydrolysis by oxytocin and the mechanism by which oxytocin controls prostaglandin synthesis in the ovine endometrium. Biochemical Journal. ,vol. 237, pp. 797- 805 ,(1986) , 10.1042/BJ2370797
Susan A. Leonhardt, Dean P. Edwards, Mechanism of action of progesterone antagonists. Experimental Biology and Medicine. ,vol. 227, pp. 969- 980 ,(2002) , 10.1177/153537020222701104
Ryosuke Sakumoto, Tokushi Komatsu, Etsuko Kasuya, Toshiyuki Saito, Kiyoshi Okuda, Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle Domestic Animal Endocrinology. ,vol. 31, pp. 246- 257 ,(2006) , 10.1016/J.DOMANIEND.2005.11.001
Cesar Labarca, Kenneth Paigen, A simple, rapid, and sensitive DNA assay procedure. Analytical Biochemistry. ,vol. 102, pp. 344- 352 ,(1980) , 10.1016/0003-2697(80)90165-7
Emmanouil Karteris, Sevasti Zervou, Yefei Pang, Jing Dong, Edward W. Hillhouse, Harpal S. Randeva, Peter Thomas, Progesterone Signaling in Human Myometrium through Two Novel Membrane G Protein-Coupled Receptors: Potential Role in Functional Progesterone Withdrawal at Term Molecular Endocrinology. ,vol. 20, pp. 1519- 1534 ,(2006) , 10.1210/ME.2005-0243
K. Okuda, S. Kito, N. Sumi, K. Sato, A study of the central cavity in the bovine corpus luteum Veterinary Record. ,vol. 123, pp. 180- 183 ,(1988) , 10.1136/VR.123.7.180
J.J. Peluso, G. Fernandez, A. Pappalardo, B.A. White, Membrane-Initiated Events Account for Progesterone's Ability to Regulate Intracellular Free Calcium Levels and Inhibit Rat Granulosa Cell Mitosis Biology of Reproduction. ,vol. 67, pp. 379- 385 ,(2002) , 10.1095/BIOLREPROD67.2.379
G.E. Mann, G.E. Lamming, Timing of prostaglandin F2α release episodes and oxytocin receptor development during luteolysis in the cow Animal Reproduction Science. ,vol. 93, pp. 328- 336 ,(2006) , 10.1016/J.ANIREPROSCI.2005.08.005
M. A. Fortier, L. A. Guilbault, F. Grasso, Specific properties of epithelial and stromal cells from the endometrium of cows Reproduction. ,vol. 83, pp. 239- 248 ,(1988) , 10.1530/JRF.0.0830239
N. Forde, M.E. Beltman, P. Lonergan, M. Diskin, J.F. Roche, M.A. Crowe, Oestrous cycles in Bos taurus cattle. Animal Reproduction Science. ,vol. 124, pp. 163- 169 ,(2011) , 10.1016/J.ANIREPROSCI.2010.08.025