Schizophrenia and Depression – Challenging the Paradigm of Two Separate Diseases

摘要: Affective symptoms, depression in particular, show high rates schizophrenia. When occurring combination with subclinical psychotic symptoms they are precursors of psychosis risk. Their increase over time is associated an risk and their decrease a fall therein. The prodromal stage severe the prepsychotic schizophrenia show, mean, more or less identical but diagnostically distinguishable from each other only after onset symptoms. In course full-blown depressive mood most frequent symptom, even than positive specific to relapse episodes too, some extent also when remits. 15–20% characterised by affective without Attempts identify prodrome relapses have not yielded consistent results. Kraepelinian model two discrete illness groups does provide adequate description functional association between observable throughout course. A based on symptom dimensions, which part functionally related differ shares individual illness, seems be closer reality. Since currently available antipsychotic antidepressant medications psychotherapeutic techniques act dimensions rather disease concepts, dimensional useful therapeutic respect as well.