Loss of T-Cell Receptor ζ Chain and p56lck in T-Cells Infiltrating Human Renal Cell Carcinoma

摘要: Abstract Cancer patients and mice bearing tumors develop a progressive immunosuppression manifested by decreased delayed-type hypersensitivity, T-cell lytic activity, diminished production of lymphokines, reduced proliferative response. The mechanisms underlying these changes are incompletely understood. We recently reported the presence marked alterations in signal transduction T-cells from long-term (28-day) tumors. hypothesized that soluble product produced tumor or resulting immune response to might be responsible for inducing T-cells. Tumor-infiltrating lymphocytes with renal cell carcinoma tested here showed, 10 11 cases, decrease expression receptor ζ chain p56 lck tyrosine kinase. major tumor-infiltrating only minor peripheral blood leukocyte supports notion defects induced exposure tumor. These results suggest may compromised their antitumor efficacy cancer. costs publication this article were defrayed part payment page charges. This must therefore hereby advertisement accordance 18 U.S.C. Section 1734 solely indicate fact.