Studies on the resistance to tolerance induction against human IgG in DDD mice

摘要: Abstract Immunological reactivity of lethally irradiated mice reconstituted with syngeneic bone marrow cells from either tolerized or normal donors was investigated using human IgG (HGG) as antigen. Bone were prepared 2 3 weeks after the injection tolerogen. The antibody response against HGG hapten-coupled recovered gradually cell transfer and within a few reached plateau level control which had received plus excess numbers thymocytes. significantly lower than that age-matched donors. Strain differences observed in rate recovery hyporesponsive state: lowered transient DDD mice, while more stable hyporesponsiveness induced C57BL/6 mice. Even latter strain tolerant state did not last longer completely disappeared by third week. Since responsiveness dependent on presence thymus host, considered to be due helper T recruited host prethymic T-cell precursors (pre-T cells) transferred cells. results suggest pre-T carry an antigen recognition site can specifically rendered tolerant, though temporarily. In contrast cells, antibody-forming Thus dichotomy tolerogen susceptibility between T- B-lymphocyte