Progesterone as a neuroprotectant in stroke

摘要: Progesterone has been shown to be neuroprotective in a number of central nervous system injury models, including cerebral ischaemia. There is still lack understanding behind progesterone’s neuropotective properties, and the purpose this project clarify some these issues. Osmotic mini-pump infusion was hypothesised more effective delivering progesterone target organ brain, when compared bolus intraperitoneal injection. pharmacokinetic profiles were between different dosing regimes. Intraperitoneal injection had short half-life both plasma while osmotic mini-pumps delivered higher concentrations particularly over longer period, which supports hypothesis. It that will reduce NO production cell death vitro. reduced nitric oxide after challenging microglia with LPS, our hypothesis nuclear receptor found not have major role attenuation. Neither microglial lines, BV-2 HAPI cells produced elevations formation ischaemic conditions. The vitro oxygen glucose deprived model ischaemia, viability neuronal cells. Also, high pharmacological exacerbated injury, does support reducing death. Progesterone administration, via infusion, better outcome vehicle treatment. After onset experimental stroke, delivery loading dose beneficial terms neurological deficit score adult male mice, we hypothesise co-morbidity can affect efficacy treatment outcomes. Aged animals an increased sensitivity experimentally induce stroke did display, outcomes measured, any benefit from NOD/ShiLtJ mice severe symptoms, resulting mortality surgery are recommended as diabetes for stroke. Hypertensive BPH/2 potential hypertensive functional intraperitoneally administered progesterone, non-treated small preliminary study. This The gold-standard assessing intervention effects across studies within subgroups use meta-analysis based on individual animal data. We would reveal lesion volume, but also discover other animals. significantly it appeared increase incidence following Furthermore, negative effect appears apparent young ovariectomised female These findings reduces volume having subgroups. This investigation clarified issues expanded properties progesterone. However, indicate further required before considered clinical trials neuroprotectant