Population choice in mapping genes for complex diseases.

摘要: The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different have different implications using linkage or linkage-disequilibrium-based approaches mapping complex genes. We argue that the choice study population is a critical factor when designing study, genetically simplified isolates more useful than diverse continental populations under most assumptions.