Management of childhood and adolescent latent tuberculous infection (LTBI) in Germany, Austria and Switzerland.

摘要: Background Majority of active tuberculosis (TB) cases in children low-incidence countries are due to rapid progression infection (latent TB (LTBI)) disease. We aimed assess common practice for managing paediatric LTBI Austria, Germany and Switzerland prior the publication first joint national guideline 2017. Methods Online-based survey amongst pediatricians, practitioners staff working public health sector between July November Data analysis was conducted using IBM SPSS. Results A total 191 individuals participated with 173 questionnaires included final analysis. Twelve percent respondents were from 60% 28% Switzerland. Proportion migrant background estimated by be >50% 58%. Tuberculin skin test (TST) interferon-γ-release-assay (IGRA), particularly Quantiferon-gold-test, reported used 86% 88%, respectively. In > 5 years a positive TST or IGRA chest x-ray commonly performed (28%). Fifty-three take different diagnostic approach ≤ years, mainly combining TST, initial testing (31%). Sixty-eight prescribe isoniazid-monotherapy: 9 (62%), 6 months (6%), 31% combination therapy isoniazid rifampicin. Dosing rifampicin below current recommendations up 22% respondents. Blood-sampling before/during treatment >90% respondents, performing chest-X-ray at end 51%. Conclusion This showed heterogeneity management LTBI. Thus, regular easily accessible educational activities up-to-date guidelines key ensure awareness quality care adolescents countries.