Effect of antiretroviral therapy in human immunodeficiency virus-infected children.
作者： Wanatpreeya Phongsamart , Pimpanada Chearskul , Keswadee Lapphra , Nottasorn Plipat , Sanay Chearskul
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摘要: BACKGROUND: The appropriate timing of antiretroviral (ARV) therapy initiation in children with human immunodeficiency virus (HIV) infection has been uncertain. There was evidence poorer outcome adults who initiated treatment at lower baseline CD4 cell count. However, early may not be possible resource-limited setting and would increased risk long term side effects non-adherence. OBJECTIVE: To elucidate the HIV-infected ARV different disease stages. MATERIAL AND METHOD: Data from medical records had followed Infectious Disease Division, Department Pediatric Siriraj Hospital were retrospectively reviewed. Clinical response data analyzed. RESULTS: From September 1996 to March 2004, there 200 patients a median age 38 (2-175) months. duration follow up period 26 (1-91) count 545 (2-5016) cells/mm3. percentage 14.25 (0.11-60). Monotherapy or dual nucleoside reverse transcriptase inhibitor (NRTI) regimens 134 (67%), HAARTwas 66 (33%) patients. survival rate HAART tended better than those NRTI but salvaged appropriately (p=0.2377). > = 15% < (p=0.0471). CONCLUSION: Initiation more resulted below 15%. regimen improve higher gain especially cases CD4<
参考文章(30)
Matthias Egger, Margaret May, Geneviève Chêne, Andrew N Phillips, Bruno Ledergerber, François Dabis, Dominique Costagliola, Antonella D'Arminio Monforte, Frank De Wolf, Peter Reiss, Jens D Lundgren, Amy C Justice, Schlomo Staszewski, Catherine Leport, Robert S Hogg, Caroline A Sabin, M John Gill, Bernd Salzberger, Jonathan AC Sterne, None, Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. The Lancet. ,vol. 360, pp. 119- 129 ,(2002) , 10.1016/S0140-6736(02)09411-4
JOSÉ MANUEL SÁNCHEZ GRANADOS, José Tomás Ramos Amador, Sira Fernandez De Miguel, MARÍA ISABEL GONZÁLEZ TOMÉ, Pablo Rojo Conejo, Paloma Ferrando Vivas, Julian Clemente Pollan, Jesús Ruiz Contreras, Angel Nogales Espert, None, Impact of highly active antiretroviral therapy on the morbidity and mortality in Spanish human immunodeficiency virus-infected children. Pediatric Infectious Disease Journal. ,vol. 22, pp. 863- 868 ,(2003) , 10.1097/01.INF.0000091282.70253.5F
Timothy R. Sterling, Richard E. Chaisson, Richard D. Moore, HIV-1 RNA, CD4 T-lymphocytes, and clinical response to highly active antiretroviral therapy. AIDS. ,vol. 15, pp. 2251- 2257 ,(2001) , 10.1097/00002030-200111230-00006
Alicia M. Johnston, Megan E. Valentine, Janet Ottinger, Ruth Baydo, Victoria Gryszowka, Cindy Vavro, Kent Weinhold, Marty St. Clair, Ross E. McKinney, Immune reconstitution in human immunodeficiency virus-infected children receiving highly active antiretroviral therapy: a cohort study. Pediatric Infectious Disease Journal. ,vol. 20, pp. 941- 946 ,(2001) , 10.1097/00006454-200110000-00006
Yazdan Yazdanpanah, Daouda Sissoko, Matthias Egger, Yves Mouton, Marcel Zwahlen, Geneviève Chêne, Clinical efficacy of antiretroviral combination therapy based on protease inhibitors or non-nucleoside analogue reverse transcriptase inhibitors: indirect comparison of controlled trials BMJ. ,vol. 328, pp. 249- 0 ,(2004) , 10.1136/BMJ.37995.435787.A6
Azra C. Ghani, William E. Henley, Christl A. Donnelly, Steven Mayer, Roy M. Anderson, Comparison of the effectiveness of non-nucleoside reverse transcriptase inhibitor-containing and protease inhibitor-containing regimens using observational databases. AIDS. ,vol. 15, pp. 1133- 1142 ,(2001) , 10.1097/00002030-200106150-00008
Gail V. Matthews, Caroline. A. Sabin, Sundhiya Mandalia, Fiona Lampe, Andrew N. Phillips, Mark R. Nelson, Mark Bower, Margaret A. Johnson, Brian G. Gazzard, Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study. AIDS. ,vol. 16, pp. 53- 61 ,(2002) , 10.1097/00002030-200201040-00008
Susan H. Eshleman, Martin Mracna, Laura A. Guay, Martina Deseyve, Shawn Cunningham, Mark Mirochnick, Philippa Musoke, Thomas Fleming, Mary Glenn Fowler, Lynne M. Mofenson, Francis Mmiro, J. Brooks Jackson, Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012). AIDS. ,vol. 15, pp. 1951- 1957 ,(2001) , 10.1097/00002030-200110190-00006
Gregory K. Robbins, Victor De Gruttola, Robert W. Shafer, Laura M. Smeaton, Sally W. Snyder, Carla Pettinelli, Michael P. Dubé, Margaret A. Fischl, Richard B. Pollard, Robert Delapenha, Linda Gedeon, Charles van der Horst, Robert L. Murphy, Mark I. Becker, Richard T. D'Aquila, Stefano Vella, Thomas C. Merigan, Martin S. Hirsch, Comparison of Sequential Three-Drug Regimens as Initial Therapy for HIV-1 Infection New England Journal of Medicine. ,vol. 349, pp. 2293- 2303 ,(2003) , 10.1056/NEJMOA030264
Robert S Hogg, Benita Yip, Keith J Chan, Evan Wood, Kevin JP Craib, Michael V O'Shaughnessy, Julio SG Montaner, None, Rates of Disease Progression by Baseline CD4 Cell Count and Viral Load After Initiating Triple-Drug Therapy JAMA. ,vol. 286, pp. 2568- 2577 ,(2001) , 10.1001/JAMA.286.20.2568