Immune reconstitution in human immunodeficiency virus-infected children receiving highly active antiretroviral therapy: a cohort study.

摘要: Background. Highly active antiretroviral therapy (HAART) has brought about rapid declines in HIV-1 RNA concentrations and an increase CD4 + counts HIV-1-infected children. These changes are often accompanied by clinical improvement; however, the extent to which immune reconstitution occurs is not known. Design. We compared two cohorts (n = 35) of children evaluate effects HAART on recovery. Cohort 1 (C1) included clinically well receiving with a >22% at study initiation. Before all had moderately severely suppressed function CDC criteria (CD4 25%) no evidence disease. Children C2 were non-HAART regimen. Methods. Immunophenotyping was performed characterize CD8 subsets regard maturation activation. T cell rearrangement excision circles (TRECs) measured quantify recent thymic emigrants. Results. No difference found percent or cells markers between C1 C2. There significantly less expression activation both C1. TREC production Conclusion. Moderately able reconstitute their systems degree that indistinguishable from stable, Class A1 subsets, cellular production.