Antimicrobial-specific cell-mediated immune reconstitution in children with advanced human immunodeficiency virus infection receiving highly active antiretroviral therapy.
作者： A. Weinberg , S. Pahwa , R. Oyomopito , V. J. Carey , B. Zimmer
DOI: 10.1086/420931
关键词: Immunity 、 Virus 、 Tetanus 、 Medicine 、 Immunology 、 Lymphocyte 、 Immune system 、 Viral load 、 Lymphocyte proliferation 、 Virology 、 Immunopathology
摘要: To identify virological and immunological correlates of microbial-specific immune reconstitution in children with advanced human immunodeficiency virus (HIV) infection, Candida- tetanus-specific lymphocyte proliferation was measured 165 initiating a new highly active antiretroviral therapy (HAART) regimen. During the study, proportions immunity to Candida tetanus increased from 53% 66% 19% 22%, respectively. Tetanus associated an HIV load < or =400 RNA copies/mL immunity. At end 23% patients baseline negative had immunity, 65% Reconstitution correlated lower end-of-study loads activated CD8+ cell percentages higher in-study CD4+ percentages, but not gain cells. showed similar trends. In conclusion, infection receiving HAART reconstituted more readily than they did suggesting role for antigen reexposure. Additional factors were low load, high levels
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