The long-term effectiveness of generic adult fixed-dose combination antiretroviral therapy for HIV-infected Ugandan children.

摘要: Background: Access to pediatric antiretroviral formulations is increasing in resource-limited countries, however adult FDCs are still commonly used by therapy (ART) programs. Objective: To describe long-term effectiveness of using FDC d4T+3TC+NVP (Triomune) children for HIV treatment. Methods: Clinical, immunologic, and virologic outcomes HIV-infected ART-naive aged six months 12 years, were evaluated up 96 weeks post-ART initiation. Results: From March 2004 June 2006, 104 followed with a median age 5.4 CD4 cell percent HIV-1 RNA 11.0% (IQR 6.7-13.9) 348,846copies/mL 160,941-681,313) respectively at baseline. Using Kaplan-Meir estimates, 75% had undetectable viral loads ( 15% 3 times more likely achieve load 5-14.9% <5%. Conclusion: Treatment generic Ugandan led sustained clinical, immunologic response during ART. Early initiation ART key achieving virological success. Key words: Children, HIV, treatment, Sub-Saharan Africa, fixed dose combination