Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus

摘要: An altered redox status and increased lymphocyte apoptosis have been implicated in the development of systemic lupus erythematosus (SLE). In this study, we evaluated relationship between glutathione (GSH) depletion, reactive oxygen species (ROS) and, progression their association with SLE severity. Significant low levels intracellular glutathione, total thiol state (GSH/GSSG) were found patients, which activated caspase-3 expression lymphocytes remarkably increased. The severity disease was positively allied caspase-3, but negatively decreased thiol, depleted (GSH/GSSG). associated GSH elevated multiple oxidative stress markers; ROS lipid peroxidation measured as malondialdehyde (MDA). These results suggest that depletion trigger may be coupled disease.