Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
作者： Dharminder Chauhan , Surender M. Kharbanda , Hiroshi Uchiyama , Mitsuyoshi Urashima , Kenneth C. Anderson
DOI: 10.1016/0145-2126(94)00132-T
关键词:
摘要: The present studies have examined the effects of pokeweed mitogen (PWM) on induction early growth response-1 gene (EGR-1) in normal human B cells. PWM regulates EGR-1 expression by both transcriptional and post-transcriptional mechanisms. Transient transfection assays with promoter fragments linked to chloramphenicol acetyltransferase (CAT) demonstrated that induced transcription is conferred CArG motif (C C[AT]6GG) promoter. results further activation S6 kinase (pp90rsk), evidenced phosphorylation serum response factor (SRF) peptides, treated Taken together, these findings suggest able initiate an intracytoplasmic signalling cascade
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