Impact of the unfolded protein response on the pathogenicity of the necrotrophic fungus Alternaria brassicicola

摘要: The unfolded protein response (UPR) is an important stress signalling pathway involved in the cellular development and environmental adaptation of fungi. We investigated importance UPR pathogenicity plant necrotrophic fungus Alternaria brassicicola, which causes black spot disease on a wide range Brassicaceae. identified AbHacA gene encoding major transcription regulator A. brassicicola. Deletion prevented induction to endoplasmic reticulum stress. Loss mutants resulted complete loss virulence was also associated with cell wall defect reduced capacity for secretion. In addition, our results showed that triggered by treatment mycelia camalexin, i.e. Arabidopsis thaliana phytoalexin, strains lacking functional exhibited increased vitro susceptibility antimicrobial metabolites. hypothesize plays role fungal altering protection against host metabolites reducing ability assimilate nutrients required growth environment. This study suggests targeting would be effective control strategy.