Sulphonamides for control of beta-amyloid production
作者： Timothy Harrison , Joanne Claire Hannam , Timothy Jason Sparey , Andrew Madin
DOI:
关键词:
摘要: There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising substitute on the bridgehead position. The compounds modulate production β-amyloid precursor protein, and hence are useful in treatment Alzheimer's Disease.
lens.org 参考文章(5)
Graeme Irvine Stevenson, Adrian Leonard Smith, Ian James Collins, Stephen John Lewis, Timothy Jason Sparey, Martin Richard Teall, Joseph George Neduvelil, Mark Steven Shearman, Patrice Charles Belanger, Joanne Claire Hannam, Andrew Madin, Alan John Nadin, Edward Giles Mciver, Timothy Harrison, Sulphonamido-substituted bridged bicycloalkyl derivatives ,(2001)
Gilbert M. Rishton, Daniel M. Retz, Paul A. Tempest, James Novotny, Steve Kahn, James J. S. Treanor, Jack D. Lile, Martin Citron, Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway : Potential small-molecule therapeutic agents for the treatment of alzheimer's disease Journal of Medicinal Chemistry. ,vol. 43, pp. 2297- 2299 ,(2000) , 10.1021/JM990622Z
K. Wiesner, Pak-Tsun Ho, R. C. Jain, S. F. Lee, S. Oida, A. Philipp, Synthesis and Rearrangement Control of Substituted Benzobicycloheptane Aziridines Canadian Journal of Chemistry. ,vol. 51, pp. 1448- 1457 ,(1973) , 10.1139/V73-219
K. Wiesner, A. Philipp, Synthesis in the series of diterpene alkaloids V. An approach to songorine Tetrahedron Letters. ,vol. 7, pp. 1467- 1470 ,(1966) , 10.1016/S0040-4039(00)75717-0
M Freed, J Potoski, Benzobicycloalkane amines for inducing analgesia ,(1972)