Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
作者： Weibo Cai , Kai Chen , Lina He , Qizhen Cao , Albert Koong
DOI: 10.1007/S00259-006-0361-6
关键词:
摘要: Purpose Cetuximab, a chimeric monoclonal antibody targeting epidermal growth factor receptor (EGFR) on the surface of cancer cells, was approved by FDA to treat patients with metastatic colorectal cancer. It is currently also in advanced-stage development for treatment several other solid tumors. Here we report first time quantitative positron emission tomography (PET) imaging EGFR expression xenograft-bearing mice using 64Cu-labeled cetuximab.
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