Improved Imaging Resolution in Desorption Electrospray Ionization Mass Spectrometry
作者： Vilmos Kertesz , Gary J. Van Berkel
DOI: 10.1002/RCM.3662
关键词:
摘要: Imaging resolution of desorption electrospray ionization mass spectrometry (DESI-MS) was investigated using printed patterns on paper and thin-layer chromatography (TLC) plate surfaces. Resolution approaching 40 m achieved with a typical DESI-MS setup, which is approximately 5 times better than the best reported previously. This improvement accomplished careful control operational parameters (particularly spray tip-to-surface distance, solvent flow rate, spacing lane scans). Also, an appropriately strong analyte/surface interaction uniform surface texture size scale no larger that desired imaging were required to achieve this resolution. Overall, conditions providing smallest possible effective desorption/ionization area in DESI impact plume region minimizing analyte redistribution during analysis led improved
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