Cyclin E low-molecular-weight isoform as a predictor of breast cancer in Japanese women.
作者： Yukiko Tokai , Shigeto Maeda , Junzo Yamaguchi , Tatsuya Uga , Naomi Hayashida
DOI: 10.9738/1400.1
关键词:
摘要: Abstract Overexpression of low-molecular-weight isoforms (LMWI) cyclin E in breast cancer cells is associated with poor prognosis and could serve a novel role progression. LMWI originate from proteolytic processing E, which deregulated hyperactive. In this study, levels full-form/LMWI were determined the use Western blot analysis 69 Japanese patients. significantly correlated known parameters such as tumor grade estrogen/progesterone receptor expression. multivariate analysis, patient survival was but not either form E. strong predictor whereas some cases early relapse overexpression lower reported. Thus, might be good complementary factor to other predictors for cancer.
allenpress.com
internationalsurgery.org参考文章(30)
Khandan Keyomarsi, Thaddeus W. Herliczek, The role of cyclin E in cell proliferation, development and cancer Progress in Cell Cycle Research. ,vol. 3, pp. 171- 191 ,(1997) , 10.1007/978-1-4615-5371-7_14
Cyclin E in breast cancer [4] (multiple letters) The New England Journal of Medicine. ,vol. 348, pp. 1063- 1064 ,(2003) , 10.1056/NEJM200303133481117
William Renyifo Cam, Tsutomu Masaki, Yasushi Shiratori, Naoya Kato, Makoto Okamoto, Yutaka Yamaji, Kouichi Igarashi, Takaaki Sano, Masao Omata, Activation of Cyclin E-Dependent Kinase Activity in Colorectal Cancer Digestive Diseases and Sciences. ,vol. 46, pp. 2187- 2198 ,(2001) , 10.1023/A:1011962915280
K. Keyomarsi, W. Toyofuku, M. P. Fox, D. Conte, Deregulation of cyclin E in breast cancer Oncogene. ,vol. 11, pp. 941- 950 ,(1995)
H J G Bloom, W W Richardson, Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. British Journal of Cancer. ,vol. 11, pp. 359- 377 ,(1957) , 10.1038/BJC.1957.43
G Contesso, H Mouriesse, S Friedman, J Genin, D Sarrazin, J Rouesse, The importance of histologic grade in long-term prognosis of breast cancer: a study of 1,010 patients, uniformly treated at the Institut Gustave-Roussy. Journal of Clinical Oncology. ,vol. 5, pp. 1378- 1386 ,(1987) , 10.1200/JCO.1987.5.9.1378
Genevieve Contesso, Gloria Saccani Jotti, Gianni Bonadonna, Tumor grade as a prognostic factor in primary breast cancer European Journal of Cancer and Clinical Oncology. ,vol. 25, pp. 403- 409 ,(1989) , 10.1016/0277-5379(89)90251-4
Peggy L. Porter, Kathleen E. Malone, Patrick J. Heagerty, Gail M. Alexander, Laura A. Gatti, Eduardo J. Firpo, Janet R. Daling, James M. Roberts, Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature Medicine. ,vol. 3, pp. 222- 225 ,(1997) , 10.1038/NM0297-222
S.-J. Jang, Y.-W. Park, M.-H. Park, J.-D. Lee, Y.-Y. Lee, T.-J. Jung, I.-S. Kim, I.-Y. Choi, M. Ki, B.-Y. Choi, M.-J. Ahn, Expression of cell-cycle regulators, cyclin E and p21WAF1/CIP1, potential prognostic markers for gastric cancer Ejso. ,vol. 25, pp. 157- 163 ,(1999) , 10.1053/EJSO.1998.0619
Hitoshi Tsuda, Teruko Takarabe, Sadako Akashi-Tanaka, Takashi Fukutomi, Takeshi Nanasawa, Toru Watanabe, Evaluation of histopathological criteria for identifying nodenegative breast cancer witn high risk of early recurrence in the nsas-bc protocol study Breast Cancer. ,vol. 7, pp. 201- 209 ,(2000) , 10.1007/BF02967461