Determinants of albumin concentration in hemodialysis patients

摘要: Hypoalbuminemia predicts mortality in hemodialysis patients with end-stage renal disease and is assumed to result from malnutrition. To investigate a possible alternative cause, we evaluated the relationships between serum albumin (Salb) levels of two positive acute-phase proteins: C-reactive protein (CRP) amyloid A (SAA). We also examined relationship Salb dialysis dose delivered (Kt/V) normalized catabolic rate (PCRn) measured during 3 consecutive months group 115 patients. Serum was monthly for 5 months. SAA were not increased majority patients, despite its low molecular weight (8 kd), predialysis concentrations independent residual function, compatible nonrenal site metabolism. Both CRP correlated negatively both by linear regression multiple analysis (P < 0.001). fibrinogen 0.005). positively PCRn = 0.001), but Kt/V. The Kt/V did correlate PCRn. While one another, neither variable When either or high, regardless Thus, there are separate factors predicting Salb--markers inflammation intake--but high proteins have greater impact on than does Activity response an important predictor independently nutritional factors.