Molecular genetics of attention-deficit hyperactivity disorder (ADHD): an update
作者： Barkur S Shastry
DOI: 10.1016/J.NEUINT.2003.08.011
关键词:
摘要: Attention-deficit hyperactivity disorder (ADHD) is a heritable and behavioral condition of childhood, affecting 5-10% school-age children worldwide. Affected patients exhibit various problems such as carelessness, restlessness, disobedience failure to stay quiet in class. The etiology ADHD not known. However, family, twin adoption studies have provided strong evidence for genetic the disorder. A genome-wide scan has identified six chromosomal loci with LOD scores suggestive linkage. Animal suggest involvement brain dopamine pathway its alteration but there no direct support this hypothesis. In addition, are at least 20 candidate genes small effect that been studied none them appear be major gene causing ADHD. Medical intervention along psychosocial therapy proved beneficial controlling ADHD, although some undesirable side effects encountered during medical treatment. future, identification environmental factors, study additive interaction factors may provide better insight into pathophysiology This lead an effective new treatment strategy.
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