What is the potential of using PI3K inhibitors in the management of breast cancer in the clinic

作者: Ingrid A Mayer

DOI: 10.2217/BMT.14.26

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摘要: SUMMARY  Even with hormone- and HER2-targeted anticancer agents, intrinsic acquired resistance is a common occurrence in estrogen receptor-positive HER2-positive breast cancers, respectively. As for triple-negative cancer, its relative uncommonness, aggressiveness impressive heterogeneity have been only few of the challenges researchers clinicians face making strides against this disease. This article reviews involvement PI3K pathway these mechanisms. It also summarizes preclinical clinical data suggesting potential combination therapy inhibitors preventing restoring sensitivity to hormone-targeted, agents chemotherapy.

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