Original article: AMELIORATION OF THE HALOPERIDOL-INDUCED MEMORY IMPAIRMENT AND BRAIN OXIDATIVE STRESS BY CINNARIZINE

摘要: Haloperidol is a classic antipsychotic drug known for its propensity to cause extrapyramidal symptoms and impaired memory, owing blockade of striatal dopamine D2 receptors. Cinnarizine calcium channel blocker with receptor blocking properties which widely used in treatment vertiginous disorders. The present study aimed see whether cinnarizine would worsen the effect haloperidol on memory function oxidative stress mice brain. (5, 10 or 20 mg/kg), haloperidol, combined was administered daily via subcutaneous route were examined weekly basis their ability locate submerged plate water maze test. Mice euthanized 30 days after starting injection. Malondialdehyde (MDA), reduced glutathione (GSH) nitric oxide (nitrite/nitrate) determined substantially performance. mean time taken find escape platform (latency) significantly delayed by (2 mg/kg, i.p.) weeks 1-8 test, compared saline control group. In contrast, those treated showed shorter latencies, indicated that learning had occurred immediately. resulted increased MDA cortex, striatum, cerebellum midbrain. GSH decreased striatum cortex. Meanwhile, (20 mg/kg) significant decrease midbrain an increase cortex These data suggest improves induced brain impairment test mice.