Positively charged dextran resin inhibits trabecular bone repair in the rabbit tibial physis.
作者： Jose A. Cobos , Jinping Yang , Renwen Zhang , Marilyn Krukowski , David J. Simmons
DOI: 10.1002/(SICI)1097-4636(19980305)39:3<458::AID-JBM16>3.0.CO;2-6
关键词:
摘要: Because exposure to positively charged dextran resin (PCDR) inhibits the growth of cultured rat and human bone cells, we tested hypothesis that PCDR might inhibit repair in vivo. Central physeal defects were created by drilling 3.0-mm holes from proximal tibial plateau into metaphysis. The left tibiae packed with neutral (control); those right filled PCDR. At end 1st, 2nd, 3rd, 10th postoperative weeks, outcomes quantitated documenting percent trabecular volume within defect. PCDR-filled showed a significant decrease formation as early 2nd week. By week, trabeculae had been reduced nearly 40%. inhibition conferred suggests could be used suppressive interpositional material.
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