Prediction of protein function and pathways in the genome era.

摘要: The growing number of completely sequenced genomes adds new dimensions to the use sequence analysis predict protein function. Compared with classical knowledge transfer from one a similar (homology-based function prediction), about corresponding genes in other (orthology-based prediction) provides more specific information protein's function, while its genomic context (context-based functional context. Whereas homology-based methods molecular protein, biological process which it plays role. These complementary approaches can be combined elucidate complete networks and biochemical pathways genome an organism. Here we review recent advances field genomic-context based prediction. Techniques are highlighted examples, including that combines homology role RNase L inhibitor maturation ribosomal RNA.