Hyponatremia Induced by Drugs

摘要: Medications make up one of the most frequent causes hyponatremia. They may induce hyponatremia by affecting either sodium and water homeostasis (diuretics) or due to syndrome inappropriate secretion antidiuretic hormone. Certain drugs (e.g., diuretics, psychotropic medications, anticonvulsants) have been implicated as established However, infrequently develops in course treatment with used everyday clinical practice including proton pump inhibitors, antibiotics, angiotensin-converting enzyme hypoglycemic agents amiodarone. Proper diagnostic approach patients low serum concentrations should involve a detailed medical history special attention use culprit medications. In cases drug-induced hyponatremia, discontinuation therapy these avoidance readministration is fully warranted given that even mild can adverse outcomes (increased mortality, cognition impairment, high risk falls fractures).