Clinical Implications and Pathogenesis of Esophageal Remodeling in Eosinophilic Esophagitis

摘要: In eosinophilic esophagitis (EoE), remodeling changes are manifest histologically in the epithelium and subepithelium where lamina propria fibrosis, expansion of muscularis propria, increased vascularity occur. The clinical symptoms complications EoE largely consequences esophageal remodeling. Available therapies have demonstrated variable ability to reverse existing esophagus. Systemic potential addressing subepithelial Esophageal dilation remains a useful, adjunctive therapeutic maneuver symptomatic adults with stricture. As novel treatments emerge, it is essential that end points account for fundamental contributions overall disease activity.