Modulation of hydration characteristics of carbohydrates in aqueous medium of γ-amino butyric acid via volumetric, rheological and time-domain longitudinal NMR relaxation studies

摘要: Abstract Carbohydrates such as saccharides and their derivatives are engaged in various biological processes transportation transmission of genetic material, enzymatic processes, regulation metabolism. γ-Amino butyric acid (γ-ABA) is a non-protein amino acts an inhibitory neurotransmitter the mammalian cerebral cortex. Volumetric, rheological spectroscopic investigations helpful to elucidate molecular interactions occurring between carbohydrates γ-ABA aqueous solution. Therefore, standard state partial molar volumes, V2° Jones-Dole viscosity B-coefficients monosaccharides derivatives, polyols disaccharides were determined molality, mB range (0.05–0.50) mol·kg− 1 solutions from precise density measurements at temperature T = (288.15–318.15) K. These data used obtain corresponding volumes transfer, ΔtrV2° change B-coefficient, ΔB for water γ-ABA. The taste quality studied solutes (carbohydrates) has been appraised presence apparent massic volumes. volumetric viscometric interaction coefficients calculated McMillan-Mayer theory solutions. expansion (∂ V2°/∂ T)P, second-order (∂2V2°/∂ T2)P dB/dT also study influence temperature. quantities have explained terms ternary system on basis co-sphere overlap model suggested by Gurney (1953). Proton (1H) NMR relaxation rates (R1) obtained different made 9:1 (w/w) (H2O + D2O) solvent, T = 300 K. results compared with our previously reported (Banipal et al., 2015, 2016) studies carried out L-glycine. stereochemical effects hydration controlled domineering conformations discussed.