Inhibition of yeast glycolysis by nitroxyl (HNO): A mechanism of HNO toxicity and implications to HNO biology
作者： Brenda E. Lopez , Chester E. Rodriguez , Mochtar Pribadi , Natalie M. Cook , Masaru Shinyashiki
DOI: 10.1016/J.ABB.2005.07.012
关键词:
摘要: Nitroxyl (HNO) was found to inhibit glycolysis in the yeast Saccharomyces cerevisiae. The toxicity of HNO positively correlated with dependence on for cellular energy. potently crucial glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH), an effect which is likely be responsible observed inhibition whole cell preparations. It proposed that GAPDH occurs through reaction active site thiolate residue GAPDH. Significantly, levels do not alter or redox status intracellular glutathione (GSH), indicating has thiol selectivity. ability environment contains relatively large concentrations GSH important aspect pharmacology and possibly, physiology.
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