Combined genetic profiles of components and regulators of the vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin
作者： Manuela Vecsler , Ronen Loebstein , Shlomo Almog , Daniel Kurnik , Boleslav Goldman
DOI: 10.1160/TH05-06-0446
关键词:
摘要: We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified effects polymorphisms in: CYP2C9, VKORC1 , calumenin (CALU), ? -glutamyl carboxylase ( GGCX ) and microsomal epoxide hydrolase (EPHX1) dose requirements.The G1542C polymorphism was associated with decreased doses hetero- homozygous mutant (21% 50% lower, respectively; p
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