Vaccination coverage against hepatitis A and B viruses, Streptococcus pneumoniae, seasonal flu, and A(H1N1)2009 pandemic influenza in HIV-infected patients.

摘要: Background Several vaccines are recommended in HIV-infected patients due to an increased risk of vaccine-preventable infections, severe forms the disease, or shared transmission routes. Few data available regarding vaccination coverage and its determinants this population. Methods A cross-sectional study was performed included a hospital-based cohort 2011. Vaccination against hepatitis A virus (HAV), B (HBV), seasonal A(H1N1)2009 pandemic influenza, invasive pneumococcal diseases (IPD) were recorded. Factors associated with assessed by multivariate logistic regression. Results 2467 (median age: 47 years; male gender 71.5%; men having sex (MSM): 43.9%; CDC stage C: 24.3%; HBV and/or C co-infection: 14.4%). Median duration HIV infection 10 years 93.1% received combination antiretroviral therapy. At baseline, median CD4 count 527 cells/mm3 viral load 200/mm3 HIV-RNA <50 copies/mL (IPD, influenza), longer follow-up experienced physician (HBV, IPD). Conclusions Vaccination remained insufficient for all infections investigated study. Determinants largely not evidence-based, efforts should be focused on improving physicians’ knowledge about guidelines.