Systems biology approaches to heart development and congenital heart disease
作者： S. R. Sperling
DOI: 10.1093/CVR/CVR126
关键词:
摘要: Even though the foundation of systems biology approaches to cardiac function was led more than fifty years ago, there has been slow progression over last few decades. Systems studies were mainly focused on lower organisms, frequently yeast. With boost high-throughput technologies, level analyses, building one backbone biology, started complement single-gene focus in fields heart development and congenital disease. A challenge is bring together many uncovered molecular components driving eventually establish computational models describing this complex developmental process. Congenital diseases represent overlapping phenotypes, reflecting modularity development. The aetiology majority disease still unknown, it suggestive that understanding biological network underlying will enhance our for its alteration. This review provides an overview framework focusing developing pathology. Recent methodological developments basis future are highlighted knowledge gained specified.
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Szabolcs Szelinger, John V. Pearson, David W. Craig, Microarray-Based Genome-Wide Association Studies Using Pooled DNA Methods of Molecular Biology. ,vol. 700, pp. 49- 60 ,(2011) , 10.1007/978-1-61737-954-3_4
A mouse for all reasons. Cell. ,vol. 128, pp. 9- 13 ,(2007) , 10.1016/J.CELL.2006.12.018
Valérie Gailus-Durner*, Helmut Fuchs*, Thure Adler, Antonio Aguilar Pimentel, Lore Becker, Ines Bolle, Julia Calzada-Wack, Claudia Dalke, Nicole Ehrhardt, Barbara Ferwagner, Wolfgang Hans, Sabine M. Hölter, Gabriele Hölzlwimmer, Marion Horsch, Anahita Javaheri, Magdalena Kallnik, Eva Kling, Christoph Lengger, Corinna Mörth, Ilona Mossbrugger, Beatrix Naton, Cornelia Prehn, Oliver Puk, Birgit Rathkolb, Jan Rozman, Anja Schrewe, Frank Thiele, Jerzy Adamski, Bernhard Aigner, Heidrun Behrendt, Dirk H. Busch, Jack Favor, Jochen Graw, Gerhard Heldmaier, Boris Ivandic, Hugo Katus, Martin Klingenspor, Thomas Klopstock Elisabeth Kremmer, Markus Ollert, Leticia Quintanilla-Martinez, Holger Schulz, Eckhard Wolf, Wolfgang Wurst, Martin Hrabé de Angelis, Systemic first-line phenotyping Methods of Molecular Biology. ,vol. 530, pp. 463- 509 ,(2009) , 10.1007/978-1-59745-471-1_25
Bas van Steensel, Steven Henikoff, Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase. Nature Biotechnology. ,vol. 18, pp. 424- 428 ,(2000) , 10.1038/74487
Yu-I Weng, Tim H.-M. Huang, Pearlly S. Yan, Methylated DNA Immunoprecipitation and Microarray-Based Analysis: Detection of DNA Methylation in Breast Cancer Cell Lines Methods in Molecular Biology. ,vol. 590, pp. 165- 176 ,(2009) , 10.1007/978-1-60327-378-7_10
James Bassingthwaighte, Peter Hunter, Denis Noble, The Cardiac Physiome: perspectives for the future Experimental Physiology. ,vol. 94, pp. 597- 605 ,(2009) , 10.1113/EXPPHYSIOL.2008.044099
Christine E. Horak, Michael Snyder, ChIP-chip: a genomic approach for identifying transcription factor binding sites. Methods in Enzymology. ,vol. 350, pp. 469- 483 ,(2002) , 10.1016/S0076-6879(02)50979-4
Silke Sperling, Christina H. Grimm, Ilona Dunkel, Siegrun Mebus, Hans-Peter Sperling, Arno Ebner, Raffaello Galli, Hans Lehrach, Christoph Fusch, Felix Berger, Stefanie Hammer, Identification and functional analysis of CITED2 mutations in patients with congenital heart defects Human Mutation. ,vol. 26, pp. 575- 582 ,(2005) , 10.1002/HUMU.20262
Alberto de la Fuente, From ‘differential expression’ to ‘differential networking’ – identification of dysfunctional regulatory networks in diseases Trends in Genetics. ,vol. 26, pp. 326- 333 ,(2010) , 10.1016/J.TIG.2010.05.001
Jizhong Zou, Morgan L. Maeder, Prashant Mali, Shondra M. Pruett-Miller, Stacey Thibodeau-Beganny, Bin-Kuan Chou, Guibin Chen, Zhaohui Ye, In-Hyun Park, George Q. Daley, Matthew H. Porteus, J. Keith Joung, Linzhao Cheng, Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell. ,vol. 5, pp. 97- 110 ,(2009) , 10.1016/J.STEM.2009.05.023