ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

作者: Takao Ohtsuka , Hoon Ryu , Yohji A Minamishima , Salvador Macip , Junji Sagara

DOI: 10.1038/NCB1087

关键词:

摘要: … response and inhibited translocation of Bax to mitochondria in … mitochondria. Our findings demonstrate that ASC has an essential role in the intrinsic mitochondrial pathway of apoptosis …

参考文章(31)
Motoshi Suzuki, Richard J. Youle, Nico Tjandra, Structure of Bax: Coregulation of Dimer Formation and Intracellular Localization Cell. ,vol. 103, pp. 645- 654 ,(2000) , 10.1016/S0092-8674(00)00167-7
Bert Vogelstein, David Lane, Arnold J. Levine, Surfing the p53 network Nature. ,vol. 408, pp. 307- 310 ,(2000) , 10.1038/35042675
H. O. Fearnhead, J. Rodriguez, E.-E. Govek, W. Guo, R. Kobayashi, G. Hannon, Y. A. Lazebnik, Oncogene-dependent apoptosis is mediated by caspase-9 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 13664- 13669 ,(1998) , 10.1073/PNAS.95.23.13664
Vanessa S Marsden, Liam O'Connor, Lorraine A O'Reilly, John Silke, Donald Metcalf, Paul G Ekert, David CS Huang, Francesco Cecconi, Keisuke Kuida, Kevin J Tomaselli, Sophie Roy, Don W Nicholson, David L Vaux, Philippe Bouillet, Jerry M Adams, Andreas Strasser, None, Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome Nature. ,vol. 419, pp. 634- 637 ,(2002) , 10.1038/NATURE01101
Krzysztof Pawlowski, Frederic Pio, Zhi-Liang Chu, John C. Reed, Adam Godzik, PAAD – a new protein domain associated with apoptosis, cancer and autoimmune diseases Trends in Biochemical Sciences. ,vol. 26, pp. 85- 87 ,(2001) , 10.1016/S0968-0004(00)01729-1
Emily M Miyashita, Bin Yang, Kitty M.C Lam, Dorothy H Crawford, David A Thorley-Lawson, A novel form of Epstein-Barr virus latency in normal B cells in vivo Cell. ,vol. 80, pp. 593- 601 ,(1995) , 10.1016/0092-8674(95)90513-8
Michael C Wei, Wei-Xing Zong, Emily H-Y Cheng, Tullia Lindsten, Vily Panoutsakopoulou, Andrea J Ross, Kevin A Roth, Grant R MacGregor, Craig B Thompson, Stanley J Korsmeyer, Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Science. ,vol. 292, pp. 727- 730 ,(2001) , 10.1126/SCIENCE.1059108
Motoshi Sawada, Weiyong Sun, Paulette Hayes, Konstantin Leskov, David A. Boothman, Shigemi Matsuyama, Ku70 suppresses the apoptotic translocation of Bax to mitochondria Nature Cell Biology. ,vol. 5, pp. 320- 329 ,(2003) , 10.1038/NCB950