Saprotrophic bacteria as a possible means of controlling the immune status of the body through regulation of metabolic reactions

摘要: An analysis of the literature allowed a theoretical grounding possibility microbial control immune status organism by use saprotrophic bacteria regulating its metabolic (i.e., enzymatic reactions). The main objective is protection from infections caused conditionally pathogenic microflora. Bacterial formulations can produce following effects: (1) decrease in activities oxidation system, glucuronyl transferase, and NAD+ glycohydrolase an increase activity glucose-6-phosphate dehydrogenase hepatic microsomes; (2) or acetylation liver lymphocytes; (3) enzymes glycolysis, hexose monophosphate shunt, NADPH oxidase as well succinate glutamate dehydrogenases, acid phosphatase, α-naphthyl acetate esterase, nonspecific immunocompetent cells; and/or (4) stimulation humoral cell-mediated immunity. To achieve over human organism, it necessary to study correlations between pharmacokinetics test substances, involved their metabolism, cell mediated reactions; determine phenotypes individuals; identify systematize normal microflora each individual; elucidate molecular mechanisms biochemical effects exerted bacteria; (5) select specific strains that secrete substances above processes. Different tactics individual immunity should be selected for subjects with different phenotypes.