Immunopharmacologic aspects of lipopolysaccharide endotoxin action with special reference to cyclic nucleotides.

摘要: Lipopolysaccharides (LPS) are responsible for the immunopharmacologic activities of endotoxins gram-negative bacteria. This chapter will discuss their actions and evidence that mediated in part by cyclic nucleotides. The lipopolysaccharides ubiquitous nature have many immunomodulatory activities. As a result, immunologists consider them ever present nuisances perturbing experiments. Clearly context endotoxemia sepsis toxicities on body’s defense systems, including hyperpyrexia, intra-vascular coagulation. reticuloendothelial system (RES) blockade, etc., can be considered host destructive. On other hand, absence disease, low doses may positive immunoregulatory contributing to more effective defense. It is possible envision as being mechanism. nonpathogenic gastrointestinal flora provides continuous level LPS acting hormonal signals promote development enhance function entire immune system. Endotoxins regulate, either directly or indirectly. almost every phase natural specific systems body. They generally growth cell populations involved. do so at concentrations (ng/ml), i.e., which periodically, even regularly. achieved locally perhaps also systemically. Finally, they appear act via nucleotide pathways hormones molecules mediating thought act. They, therefore, qualify messengers receptors physiologically constructive ways.