Immunobiology and Immunopharmacology of Bacterial Endotoxins

摘要: Endotoxins are constituents of all gram negative bacteria, as well many other microorganisms. Since their original discovery and study at the beginning middle parts this century, investigations have been performed concerning immunochemistry physicochemistry, pharmacologic activities physiologic effects on host. It became widely recognized during century that pyrogenicity microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety illnesses including neoplasia, such "pyrogens," Le., bacterial endo toxins. Inconclusive results observed detrimental ones as, in cases, beneficial ones. accepted organisms fever occurring patients, untoward pathophysiological infections, seemed due endotoxin bacteria contained or released. In regard, septic shock has studied detail by clinicians, physiologists pharmacologists made relate devastating infection metabolic alterations caused Recently, however, also studied."