Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: Present situation, predicaments, and perspectives

摘要: Pancreatic cancer is highly lethal, and the most effective treatment curative resection followed by chemotherapy. Unfortunately, chemoresistance an extremely common occurrence, novel modalities, such as immunotherapy molecular targeted therapy, have shown limited success in clinical practice. characterized abundant stromal compartment. Cancer-associated fibroblasts (CAFs) extracellular matrix they deposit account for a large portion of pancreatic tumor stroma. CAFs interact directly indirectly with cells can compromise effects of, even promote tumorigenic responses to, various approaches. To eliminate these adverse effects, depletion strategies were developed. Instead anticipated antitumor depletion, more aggressive phenotypes occasionally observed. The failure universal led to investigation heterogeneity that forms foundation remodeling normalization. This review analyzes role therapeutic resistance discusses potential CAFs-targeting basing on diverse biological functions CAFs, thus improve outcome treatment.