The epidermal growth factor receptor in human pancreatic cancer.
作者： Nicholas R. Lemoine , Christine M. Hughes , Claire M. Barton , Richard Poulsom , Rosemary E. Jeffery
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摘要: The epidermal growth factor receptor (EGFR) and its ligands are thought to be important in the control of proliferation many epithelial systems, including exocrine pancreas. Abnormalities expression two known EGFR, transforming alpha factor, occur frequently ductal adenocarcinoma human We have examined an archival series cases pancreatic pathology for EGFR using anti-EGFR antiserum 12E found that there is almost ubiquitous overexpression cancer chronic pancreatitis. Southern blot analysis showed no evidence amplification or rearrangement gene. conclude autocrine loop involving system may involved genesis both neoplasia reactive hyperplasia epithelium.
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