Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women.

摘要: Cyclical hormonal changes during an ovarian cycle may affect immune responses, which is crucial for the embryonic implantation. We aim to investigate whether levels and activity of T, B, NK cells change a menstrual cycle. Twenty-two normally cycling women were enrolled peripheral blood was drawn serially Intracellular cytokine expression CD3 + CD4 CD8 cells, Th1/Th2 cytokine-producing T cell ratios determined using flow cytometric analysis. cytotoxicity measured by analysis at E:T 50:1, 25:1, 12.5:1 also LU 20%. Proportions (percentage) ( p = 0.046) 0.002) increased in follicular phase compared with luteal phase. The − CD56 0.010) dim 0.012) ratio 20% significantly Even though IL-10–producing lower midluteal as early phase, proportions CD19 B NKT Th1 subsets, not changed conclude that well are Neuroendocrine regulation on responses suggested cycle, be critical implantation pregnancy.