A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus.
作者： Takatoshi Ueki , Masamitsu Tanaka , Kanna Yamashita , Sumiko Mikawa , ZheFu Qiu
DOI: 10.1523/JNEUROSCI.23-37-11732.2003
关键词:
摘要: Neurogenesis occurs in restricted regions the adult mammalian brain, among which neurogenesis hippocampal dentate gyrus plays crucial role learning and memory. To date, little is known about neurogenic cues, result neuronal fate adoption of neural stem cells residing regions, especially cues neurogenesis. In present study, we show that astrocytes also granule adjacent to secrete a newly cloned novel secretory factor, Neurogenesin-1. This protein contains three cysteine-rich domains unique sequence contributes differentiation brain by preventing glial fate. Furthermore, activity detected culture medium was markedly suppressed administration an anti-Neurogenesin-1 antibody. These findings suggest endogenous mechanisms induce propose innovative treatment for neurodegenerative diseases cause loss neurons.
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