Camu-camu seed (Myrciaria dubia) – From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient

摘要: Camu-camu (Myrciaria dubia) seeds are discarded without recovering the bioactive compounds. The main aim of present work was to optimise solvent mixture extract higher total phenolic content and antioxidant capacity camu-camu seeds. optimised system increased extraction compounds, in which vescalagin castalagin were displayed measured by different chemical biological assays, exerted antiproliferative cytotoxic effects against A549 HCT8 cancer cells, antimicrobial effects, protected human erythrocytes hemolysis, inhibited α-amylase α-glucosidase enzymes presented vitro antihypertensive effect. Additionally, optimized LDL copper-induced oxidation reduced TNF-α release NF-κB activation macrophages cell culture. Thus, use seed showed be a sustainable way recover compounds with functional properties.