Some Like it Hot: Cardioprotective Effect of Curcumin in Chronic Kidney Disease

摘要: Chronic kidney disease (CKD) is a progressive loss of structure (i.e., proteinuria, abnormal urinary sediment, abnormalities on imaging studies) and function glomerular filtration rate (GFR) <60 mL/min per 1.73 m) over period 3 months or longer which leads to accumulation water, waste, toxic substances in the body that are normally excreted by [1]. The presence CKD confers markedly increased risk cardiovascular disease, fact patients with die primarily from complications rather than end-stage renal failure [2, 3]. plays central role electrolyte balance, volume, blood pressure regulation; all these parameters have significant impact health [4]. If kidneys fail work properly, fluid builds up quickly lungs heart leading hypervolemia. This increases workload could lead chronic due volumeoverload venous low systematic arterial [5]. turn reduces net perfusion pressure, further reducing stimulating many neurohumoral factors such as renin–angiotensin–aldosterone system (RAAS), sympathetic nervous system, including adrenals, arginine–vasopressin maintain supply [6]. In addition, metabolic disturbances accelerate atherosclerotic process causing vascular calcification stiffness overload. Histopathological studies indicate capillary density reduced hypertrophied myocardium, pronounced interstitial fibrosis dominant feature CKD-associated structural myocardial remodeling Furthermore, higher rates arrhythmias sudden death observed shifts balance substrate. Therefore, primary secondary prevention future events remains an important clinical goal. There four types traditional medicine used CKD: 1) angiotensin-converting enzyme inhibitors (ACEIs); 2) angiotensin II receptor blockers/antagonists (ARBs); 3) beta-blockers; 4) statins. Unfortunately, drugs therapies currently for treatment rarely effects associated numerous negative side emerging search alternative strategies prevent cardiac CKD. study Cecilia Zazueta’s group sought determine effect curcumin treating dysfunction rats established [7]. their previous study, they reported pre-treatment subjected subtotal nephrectomy, prevented increase systolic (SBP), preserved * Elena N. Dedkova elena_dedkova@rush.edu