Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors.
作者： Xiaochen Wei , Sangeetha P. Sumithran , A. Gabriela Deaciuc , Harold R. Burton , Lowell P. Bush
DOI: 10.1016/J.LFS.2005.09.009
关键词:
摘要: A novel pyridine derivative, 3,5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers 1,1'-dimethyl-[2,3']bipyrrolidinyl were isolated from the root Nicotiana tabacum plants identified as alkaloids by GC-MS analysis. The structures these new confirmed total synthesis. affinities alkaloids, other structurally related compounds for alpha4beta2*, alpha7* neuronal nicotinic acetylcholine receptors (nAChRs), nAChRs mediating nicotine-evoked dopamine release rat striatum also assessed. results indicate that do not interact with nAChRs, but inhibit [3H]nicotine binding to alpha4beta2* nAChR subtype. demonstrate act antagonists at striatum.
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