摘要: Paget's disease of bone is a focal disorder that common among older people Western European descent. It an unusual disorder, for although we now have safe and highly effective treatment, there are many aspects its pathogenesis natural history do not yet understand. Recent years seen significant advances in the understanding epidemiology, genetics molecular biology, but integrated view incorporates all these remains elusive. In this review examine some outstanding problems, solutions to which seem likely change our cell biology.
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