Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12.
作者： Zongtao Xie , Liming Cai , Runsheng Li , Jinyu Zheng , Hongyan Wu
DOI: 10.1007/S13277-015-3340-3
关键词:
摘要: microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in development Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, was down-regulated both tumor tissues and cells. Inhibition promoted cells invasion by using an assay. Furthermore, could regulate SUZ12 as shown luciferase reporter Western blot assays. Aberrant expression molecular changes (E-cadherin, N-cadherin, Vimentin) epithelial mesenchymal transition (EMT). conclusion, our study revealed may play essential progression NSCLC.
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