The induction of cardiac ornithine decarboxylase by β2 -adrenergic agents is associated with calcium channels and phosphorylation of ERK1/2.
作者： Andrés J. López-Contreras , Maria Eugenia de la Morena , Bruno Ramos-Molina , Ana Lambertos , Asunción Cremades
DOI: 10.1002/JCB.24540
关键词:
摘要: The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by beta-adrenergic agents may have heart hypertrophy is controversial issue. Besides, signaling pathways related to ODC regulation not been fully elucidated. Here we show Balb C mice stimulation activity adrenergic was mainly mediated β2-adrenergic receptors, and this lower hypertrophic heart. Interestingly, abolished L-calcium channel antagonists verapamil nifedipine. In addition, whereas treatment with associated both increases ODC, ODC-antizyme inhibitor 1 (AZIN1), c-fos c-myc mRNA levels phosphorylation CREB MAP kinases ERK1 ERK2 (ERK1/2), co-treatment blockers differentially prevented most these changes. These results suggest activation through participation channels, itself p-CREB does appear be sufficient for transcriptional ODC. post-translational mechanisms AZIN1 increase activity. J. Cell. Biochem. 114: 1978–1986, 2013. © 2013 Wiley Periodicals, Inc.
sci-hub.se 参考文章(55)
N.H. Bishopric, B Sato, K.A. Webster, Beta-adrenergic regulation of a myocardial actin gene via a cyclic AMP-independent pathway. Journal of Biological Chemistry. ,vol. 267, pp. 20932- 20936 ,(1992) , 10.1016/S0021-9258(19)36778-X
M. Faure, T.A. Voyno-Yasenetskaya, H.R. Bourne, cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. Journal of Biological Chemistry. ,vol. 269, pp. 7851- 7854 ,(1994) , 10.1016/S0021-9258(17)37127-2
M.S. Abrahamsen, R.S. Li, W Dietrich-Goetz, D.R. Morris, Multiple DNA elements responsible for transcriptional regulation of the ornithine decarboxylase gene by protein kinase A. Journal of Biological Chemistry. ,vol. 267, pp. 18866- 18873 ,(1992) , 10.1016/S0021-9258(19)37041-3
Yehia Daaka, Louis M. Luttrell, Robert J. Lefkowitz, Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. ,vol. 390, pp. 88- 91 ,(1997) , 10.1038/36362
Marie A. BOGOYEVITCH, Monica B. ANDERSSON, Judith GILLESPIE-BROWN, Angela CLERK, Peter E. GLENNON, Stephen J. FULLER, Peter H. SUGDEN, Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy. Biochemical Journal. ,vol. 314, pp. 115- 121 ,(1996) , 10.1042/BJ3140115
F FLAMIGNI, C ROSSONI, C STEFANELLI, C CALDARERA, Polyamine metabolism and function in the heart Journal of Molecular and Cellular Cardiology. ,vol. 18, pp. 3- 11 ,(1986) , 10.1016/S0022-2828(86)80977-4
Yang Xiang, Brian K Kobilka, Myocyte Adrenoceptor Signaling Pathways Science. ,vol. 300, pp. 1530- 1532 ,(2003) , 10.1126/SCIENCE.1079206
JACK G. COPELAND, DOUGLAS F. LARSON, WILLIAM R. ROESKE, DIANE H. RUSSELL, J.R. WOMBLE, β2‐ADRENOCEPTORS REGULATE INDUCTION OF MYOCARDIAL ORNITHINE DECARBOXYLASE IN MICE in vivo British Journal of Pharmacology. ,vol. 75, pp. 479- 483 ,(1982) , 10.1111/J.1476-5381.1982.TB09164.X
C. Bello-Fernandez, G. Packham, J. L. Cleveland, The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 7804- 7808 ,(1993) , 10.1073/PNAS.90.16.7804
Carmen M. Bastida, Asunción Cremades, Maria T. Castells, Andrés J. López-Contreras, Carlos López-García, Francisco Tejada, Rafael Peñafiel, Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization. Endocrinology. ,vol. 146, pp. 666- 674 ,(2005) , 10.1210/EN.2004-1004