β2‐ADRENOCEPTORS REGULATE INDUCTION OF MYOCARDIAL ORNITHINE DECARBOXYLASE IN MICE in vivo

摘要: The pharmacological characteristics of the myocardial adrenoceptor mouse have been examined during embryogenesis by measuring ornithine decarboxylase (ODC, EC 4.1.1.17) induction. 2 A four fold elevation ODC activity was observed after isoprenaline (10 mg/kg, s.c.), and enzyme increased two to three following adrenaline (1 s.c.) or terbutaline given direct injection foetus microgram/500 mg). 3 Pretreatment with beta-adrenoceptor antagonist, propranolol mg/kg), totally blocked increase in activity. 4 Elevation not inhibited metoprolol, a relatively specific at dose 10 mg/kg. 5 Since antagonist (propranolol) stimulated terbutaline, beta 2-agonist, we conclude that 2-adrenoceptors are selectively coupled regulation murine cardiac catecholamine stimulation.