Cancer gene therapy using mesenchymal stem cells

摘要: Cellular and gene therapies represent promising treatment strategies at the frontier of medicine. Hematopoietic stem cells, lymphocytes, mesenchymal cells (MSCs) can all serve as sources for use in such therapies. Strategies therapy are often based on those cell therapy, it is anticipated that some examples will be put to practical near future. Given their ability support hematopoiesis, MSCs may useful enhancement engraftment, acceleration hematopoietic reconstitution. Furthermore, advance severe graft-versus-host disease, immunosuppressive ability. This application also homing behavior sites injury inflammation. Interestingly, possess tumor-homing ability, opening up possibility applications targeted delivery anti-cancer genes tumors. Many reports have indicated utilized target tumors deliver molecules locally, recognized non-healing wounds with inflammatory tissue. Here, we review both potential cellular vehicles cancer molecular mechanisms underlying MSC accumulation tumor sites.