Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma
作者： Jing-Jing Zhang , Yi Zhu , Yan Zhu , Jun-Li Wu , Wen-Biao Liang
DOI: 10.1007/S12094-012-0770-X
关键词:
摘要: Introduction Epigenetic modifications play an important role in multistage carcinogenesis. The of the three functional DNA methyltransferases (DNMTs) pancreatic carcinogenesis has not been fully understood. main goal this study was to examine DNMT expression different stages ductal adenocarcinoma (PDAC), and evaluate their prognostic significance PDAC.
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Axel Walch, Katja Specht, Jan Smida, Michaela Aubele, Horst Zitzelsberger, Heinz Höfler, Martin Werner, Tissue microdissection techniques in quantitative genome and gene expression analyses Histochemistry and Cell Biology. ,vol. 115, pp. 269- 276 ,(2001) , 10.1007/S004180100253
JR Melki, P Warnecke, PC Vincent, SJ Clark, Increased DNA methyltransferase expression in leukaemia Leukemia. ,vol. 12, pp. 311- 316 ,(1998) , 10.1038/SJ.LEU.2400932
Manel Esteller, Epigenetics in Cancer The New England Journal of Medicine. ,vol. 358, pp. 1148- 1159 ,(2008) , 10.1056/NEJMRA072067
Norihiro Sato, Hiroyuki Matsubayashi, Tadayoshi Abe, Noriyoshi Fukushima, Michael Goggins, Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling. Clinical Cancer Research. ,vol. 11, pp. 4681- 4688 ,(2005) , 10.1158/1078-0432.CCR-04-2471
Bong-Kyeong Oh, Haeryoung Kim, Hye-Jung Park, Yhong-Hee Shim, Jinsub Choi, Chanil Park, Young Park, DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation International Journal of Molecular Medicine. ,vol. 20, pp. 65- 73 ,(2007) , 10.3892/IJMM.20.1.65
Anirban Maitra, N Volkan Adsay, Pedram Argani, Christine Iacobuzio-Donahue, Angelo De Marzo, John L Cameron, Charles J Yeo, Ralph H Hruban, Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray Modern Pathology. ,vol. 16, pp. 902- 912 ,(2003) , 10.1097/01.MP.0000086072.56290.FB
M Okano, Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells Nucleic Acids Research. ,vol. 26, pp. 2536- 2540 ,(1998) , 10.1093/NAR/26.11.2536
Yukihiro Yokoyama, Yuji Nimura, Masato Nagino, Advances in the treatment of pancreatic cancer: Limitations of surgery and evaluation of new therapeutic strategies Surgery Today. ,vol. 39, pp. 466- 475 ,(2009) , 10.1007/S00595-008-3904-6
Steven R Hustinx, Lorenzo M Leoni, Charles J Yeo, Priscilla N Brown, Michael Goggins, Scott E Kern, Ralph H Hruban, Anirban Maitra, Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion. Modern Pathology. ,vol. 18, pp. 959- 963 ,(2005) , 10.1038/MODPATHOL.3800377
Anne C. Ferguson-Smith, John M. Greally, Epigenetics: perceptive enzymes. Nature. ,vol. 449, pp. 148- 149 ,(2007) , 10.1038/449148A